This is a bug when the Red Dead Redemption 2 game uses the Vulkan API interface. The solution is to change the DX12 API. The specific operations are as follows:

1) On the game title interface, press the left joystick to enter the setting interface;

2) In the setting interface, select the graphics setting;

3) Select windowed in the screen type, and press A to confirm;

4) At this time, you are already in windowed mode, press the window maximize icon in the upper right corner to maximize the window. At this time, you can see the complete setting content;

5) Drag the settings down, enter the advanced settings area, and unlock the advanced settings;

6) Then in the graphics API, change the graphics API from Vulkan to DirectX 12, and then press A to confirm;

7) The game will prompt you that the settings need to be restarted to take effect. At this time, you can restart the game by pressing X for a long time. After restarting the game, you will enter the Direct 12 mode, and enter the graphics settings again. At this time, change the game to windowed full-screen mode. Or in full screen mode, there will no longer be a situation where the picture is not centered.